Tiger Balm is a product designed to offer instant relief to pain. Participants in placebo group were given calcium carbonate tablets (CFDA: H10950029), whose main ingredients are calcium and vitamin D, with recommended dose of 600 mg daily. Given the high incidence of AIMSS, identification of therapy to ameliorate these treatment emergent toxicities is important to optimize persistence with therapy and quality of life. Tiger Balm is a brand-name topical medication used to alleviate pain. Dr. Wenping Lu received financial support from National Natural Science Foundation of China (NSFC), H2902 and H2704. "The idea that tiger parts, including meat, bones, teeth, paws and eyes have magical aphrodisiac functions might be purely based on the tiger's powerful image in traditional Chinese society," said Zhang. Limbs contracture, palpitation, epilepsy, rectocele, anal fistula, arthritis. Joint pain and headaches are common side effects. Considering that breast cancer is a hormone-related disease, we also assayed estradiol () and follicle-stimulating hormone (FSH) from patients’ serum samples at the baseline, week 6, and week 12 time point, so as to see if the intervention would influence patients’ hormone levels. In traditional Chinese medicine, tiger bones are believed to help cure conditions like rheumatism and arthritis, along with erectile dysfunction. "Traditional Chinese medicine promotes a different system from Western medicine and in this system, China can call the shots," adding that revival and export of traditional Chinese medicine fits China's idea of promoting the "China model" of development. You get it as a shot. In traditional Chinese medicine, tiger wine, made using powdered bones, allegedly cures many ills including ulcers, cramp, rheumatism, stomach … Background. Lv, and Z.-L. Sun, “Clinical study of acupuncture intervention in muscle, bone and joint pain caused by aromatase inhibitors in the treatment of breast cancer,”, J. J. Mao, D. W. Bruner, C. Stricker et al., “Feasibility trial of electroacupuncture for aromatase inhibitor—related arthralgia in breast cancer survivors,”, H. Greenlee, K. D. Crew, T. Shao et al., “Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer,”, M. Kubo, H. Onishi, S. Kuroki et al., “Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer,”, M. L. Galantino, K. Desai, L. Greene, A. Demichele, C. T. Stricker, and J. J. Mao, “Impact of yoga on functional outcomes in breast cancer survivors with aromatase inhibitor-associated arthralgias,”, N. Peng, Y. Zhang, C. Ma et al., “Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: A Study Protocol For A Multicenter, Randomized, Controlled Clinical Trial,”, H. X. Zhongshen Liu and G. Li, “Effects of collagen factor on aging mice bone strength and composition,”, R. L. Yuming Fan, “Effects of bionic tiger bone on osteoporosis caused by tretinoin of rats,”, R. H. Dworkin, D. C. Turk, K. W. Wyrwich et al., “Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations,”, J. Kitawaki, “Review Endometriosis: the pathophysiology as an estrogen-dependent disease,”. Most of them were diagnosed I to II pathological stage. "The sellers are there for the money and the buyers are there to show off," said Zhang. For example, the Guilin Xiongsen Bear and Tiger Park in southern China is said to house 1,800 tigers. Impossible to find at normal pharmacies and on online shopping sites, it's been an open secret that those with connections to zoos, farms and wildlife parks could access tiger skin and bone products. Health-Related Quality of Life (HRQoL) was measured by the Functional Assessment of Cancer Therapy-Breast (FACT-B). China’s licensed domestic trade in leopard bone wine and pills is a major driver … The report said the farm considered the tiger carcasses to be worth a fortune and had been waiting for the lift of the tiger products ban. Above all, with more evidence proving the benefit of long-term AI therapy in the adjuvant setting, AI-induced arthralgia is becoming one of major issues for breast cancer survivors. This trial is registered with ChiCTR-IPR-15007081. We use cookies to improve our service for you. The device is … Other parts, like its whiskers, are worn as talismans or protective charms or used to sooth toothaches. The authors declare that they have no competing interests. 2017, Article ID 2478565, 8 pages, 2017. https://doi.org/10.1155/2017/2478565, 1Oncology Department, Guang’anmen Hospital, No. Between 2000 and 2015, 1,750 tiger part products were seized in Asia. Aromatase inhibitors (AIs) are used for adjuvant therapy of breast cancer; however AIMSS (AI-Associated Musculoskeletal Symptoms) can negatively affect quality of life and compliance. Yifan Li and Zhenhua Zhang performed data analysis and interpretation. And more than half of the patients took anastrozole instead of letrozole and exemestane. Joint symptom incidence rate and severity of the pain including average pain, worst pain, pain interference severity, stiffness, and joint symptom interference by M-BPI and VAS were used as the primary outcomes. And the major pathogenesis of bone rheumatism is that the deficiency of kidney essence results in failure to nourish the related body constituents and organs, especially bone and joints; thus pathogenic factors such as wind and cold would take advantage of the deficiency to “hit” body. Chinese traditional medicine theory considers that kidneys are generating essence and governing bones. That might be mainly due to the impact on pain of TB, and the pain was improved, thus influencing participants’ physical well-being, which indicates that TB has no significant effect on other parts of life for breast cancer patients treated with AIs. In conclusion, these results strongly suggest that TB is effective and safe in decreasing AIMSS of hormone receptor-positive breast cancer women. I don't know why Kim has real tiger bone wine either, I've never been to North Korea. Similarly, a 2015 report published by the periodical Southern Weekly said a farm in northeast China's Heilongjiang province was found to be storing the remains of more than 200 tigers in a refrigerator. More than half of the participants were naturally menopausal. Hence bionic TB powder has taken place of TB and has been widely used in clinical practice to treat osteoporosis and arthrosis. Most patients in China moved to TCM (traditional Chinese medicine) for help. One traditional remedy is a medicinal tiger bone wine, made with ground tiger bones and up to 147 herbs and spices. In this study, no significant differences were found in serum and FSH change after 12 weeks’ intervention, both in 2 groups, which proved that TB had no impact on AIs’ curative effect on breast cancer, ensuring the safety of TB treating AIMSS. We are committed to sharing findings related to COVID-19 as quickly as possible. At baseline, mean pain value was 6.3 and 6.4 () for the TB and placebo groups, respectively. The numerical rating scale ranges from 0 to 10, with 10 indicating the greatest severity or interference. There are still many deficiencies due to our limitations that should be focused on in further study. Patients completed the M-BPI, VAS, and FACT-B at baseline, 6 weeks, and 12 weeks. The baseline characteristics of the unevaluable participants were not significantly different from the treated groups. Tiger bone (TB) is one precious Chinese medicine material. They typically consist of one anode, and one or more cathodes. What is more, the results of MA.17R clinical trials showed that patients received 10 years’ AI treatment could get more benefits than those received 5 years’ therapy on American Society of Clinical Oncology (ASCO), 2016. The M-BPI is one of the most widely used instruments to measure pain in cancer patients and has been demonstrated to be a reliable, valid, and responsive measure [8]. Tiger bones treat ulcers, typhoid, malaria, dysentery, burns and even rheumatism. Juling Jiang and Wenxin Ma collected and assembled the data. Serum and FSH were tested every 6 weeks. There was no reason given for removing the ban and the announcement drew condemnation from wildlife activists along with doctors of traditional Chinese medicine and Chinese consumers. Besides, longer-term studies are necessary to confirm the durability of the response. Osteostrong is a franchise brand that offers osteogenic loading. The good news is that we noted many patients with AIMSS could get satisfying relief by bionic TB powder in clinical practice, with rare bad effects. Last but not least, the authors would like to thank all the enrolled breast cancer patients for their trust and persistence. At 12 weeks, the mean M-BPI average pain score was 2.0 and 5.6 () for the TB and placebo groups, respectively, corresponding to 50% improvement in scores compared with baseline in the TB group. Tiger parts have been used in traditional Chinese medicine (TCM) for centuries. Modified Brief Pain Inventory (M-BPI) and pain Visual Analog Scale (VAS) were adopted to evaluate the pain and functional status. In traditional Chinese medicine, tiger bones are believed to help cure conditions like rheumatism and arthritis, along with erectile dysfunction. And 2 participants failed to continue the intervention. Given tigers are protected animals, scientists adopted bionic research method to develop bionic tiger bone powder, which has similar ingredients to natural tiger bone. The Effect of Tiger bone Property. Primarily, Tiger Balm works by intercepting pain signals before they … In a cross-sectional survey of 200 patients receiving adjuvant AI therapy for breast cancer, 94 (47%) reported AI-associated joint pain, and 88 (44%) reported joint stiffness; about 13% of patients discontinued therapy because of musculoskeletal symptoms [4]. Over the past decade, the park has been wracked by scandal and accused of selling illegally produced tiger products. However, given the profound benefits associated with these medications, the majority of patients suffering from AIMSS choose to continue AI therapy. All evaluable patients were randomly assigned. Developed by bionic research method, bionic tiger bone powder shows no significant differences with natural tiger bone in ingredients and pharmacologic effects. Statistical significance will be defined as two-sided value of <0.05. M-BPI and VAS were used as the primary outcomes. Tiger bone crushed and made into a paste has been said to be usable to treat a variety of ailments, including rheumatism and back pain. Aromatase inhibitors (AIs) are used for adjuvant therapy of breast cancer; however AIMSS (AI-Associated Musculoskeletal Symptoms) can negatively affect quality of life and compliance. 72 patients were enrolled, of which 70 were evaluable. However, most patients cannot get satisfying effects [5]. Contact It is most often used as additional therapy, or … We described demographic, clinical, and outcome variables by using means and standard deviations for continuous variables and percentages for categoric variables by treatment group. Privacy Policy | Menthol, eucalyptus, and oil of wintergreen are believed to relieve pain by briefly inducing a sensation of discomfort, possibly serving as a distraction from the pain.2 Such formulations are called counterirritants and offer temporary pain relief. Bionic TB powder shows the functions of anti-inflammation, abirritation, sedation, healing fracture, and improving bone strength [26, 27]. No change of serum estradiol and FSH between two groups. Send Facebook Twitter reddit EMail Facebook Messenger Web Whatsapp Web Telegram linkedin. You can find more information in our data protection declaration. Larger number of participants should be enrolled so that the result would be more convincing. Modern studies have shown prominent anti-inflammatory, analgesic, and antiosteoporotic effects of bionic TB [7]. This supported a market for exclusive luxury goods sought by rich and powerful Chinese. Baseline demographics and clinical characteristics were comparable between the two groups (Table 1). Studies show that it works extremely well if force production is sufficient- 4.2x multiple of body weight for the lower extemity bones is he minimum require to elicit the steoblastic activity and inner bone growth. One patient immigrated to Japan, and another patient had scheduling difficulties to continue. This is an improvement that has been shown to be clinically meaningful in studies of other chronic pain conditions and that is the cut-off recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials consensus committee [28]. The FACT-B scale has 5 response levels (“not at all” to “very much”), where higher scores reflect better well-being and fewer symptoms. It has been proved that AI is more effective in decreasing the risk of recurrence of breast cancer than Tamoxifen [1], which indicates the important role of AI for adjuvant therapy of postmenopausal breast cancer. And 31 patients reported stiffness at baseline in TB group, and 27 of them reported over 2 points’ decrease (87.1%). No real tiger bone wine in China, China has less than 30 wide tigers, like 6-7 k tigers in the zoo. I would be very surprised if there was. Legal notice | "Traditional Chinese medicine is just one big lie and the doctors are scammers," an angry Weibo user said in a comment. Results. Rhino horn is ground into a powder and is considered either to be a pain killer and a detoxifying agent. Dr. Wenping Lu, Yifan Li, Zhenhua Zhang, Feifei Cui, Jialing Liu, Yitong Wang, Juling Jiang, and Wenxin Ma approved of the final manuscript. No significant benefits were observed in women randomly assigned to placebo group. Bone stimulators are devices that act as a constant-current source. ", Read more: Indonesia makes arrests over slaughtered endangered tiger, Stolen African donkeys sate Chinese demand for traditional medicine. Review articles are excluded from this waiver policy. After the announcement, China's Sina Weibo erupted with criticism. The median age of the women enrolled was 57 years (range, 27 to 73 years). Zhang Li, a doctor practicing traditional medicine at Shanghai's Jinyang Community Medical Center, said the market for tiger and rhino products is driven by rich customers who have a need to show off social status, rather than seeking relief from medical issues. In this study, we confirmed that postmenopausal women with AI-induced arthralgia demonstrate an improvement in joint pain, stiffness, and functional ability after 12 weeks of TB therapy. Baseline demographics and clinical characteristics. In the UK there are shops that sell traditional Chinese medicine and some of these products contain tiger bone. There are 3,900 tigers and 29,000 rhinos left in wild across Asia and Africa, according to the WWF. Due to the unknown mechanism of AIMSS, common treatments mainly aim at relieving the symptoms, including nonsteroidal anti-inflammatory drugs, analgesics, calcitriol agents, vitamin D, and exercise. In December 2005, Save the Tiger Fund (STF), a program of the National Fish and Wildlife Foundation, entered into a three-year agreement with the American College of Traditional Chinese Medicine to conduct a global campaign against the use of tiger bone as a medicine and tonic. Inclusion criteria were the following: (1) pathologically confirmed stage 0 to III breast cancer with no recurrence and metastasis, (2) postmenopausal women including ovarian suppression and natural postmenopause, (3) current use of a third-generation aromatase inhibitor (anastrozole, letrozole, or exemestane) for no more than one month, (4) accompanied by recent symptoms of joint pains, (5) Eastern Cooperative Oncology Group performance status 0–III, and (6) provided written informed consent before enrollment. Indications. Similar findings were seen for worst pain (3.9 versus 8.0), pain interference severity (1.9 versus 5.3), stiffness (2.4 versus 6.9), and joint symptom interference (1.8 versus 5.7), all . 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